Neurotoxin Storage Requirements
By Stcki · 6 min read · March 2026
Most neurotoxins must be refrigerated at 2–8°C (36–46°F) before and after reconstitution. Two exceptions: Daxxify can be stored at room temperature before reconstitution, and Xeomin can remain at room temperature for up to 36 months unopened. All reconstituted neurotoxins must be used within 24 hours — no exceptions.
Storage requirements by product
| Product | Manufacturer | Unopened Storage | Room Temp OK? | After Reconstitution | Notes |
|---|---|---|---|---|---|
| Botox | AbbVie/Allergan | Refrigerate 2–8°C | No | 24 hours, refrigerated | Do not freeze reconstituted product |
| Dysport | Galderma | Refrigerate 2–8°C | No | 24 hours, refrigerated | Protect from light |
| Xeomin | Merz | Refrigerate 2–8°C | Yes — up to 36 months | 24 hours, refrigerated | Longest shelf life flexibility |
| Jeuveau | Evolus | Refrigerate 2–8°C | No | 24 hours, refrigerated | Standard cold chain |
| Daxxify | Revance | Room temperature OK | Yes | 24 hours | Peptide stabilizer enables room temp |
| Letybo | Hugel/Evolus | Refrigerate 2–8°C | No | 24 hours, refrigerated | Newest product — standard storage |
Why storage matters for your bottom line
Neurotoxins are among the most expensive products in an aesthetic practice — typically $5–7 per unit at cost, $10–18 per unit at retail. A single 100-unit vial of Botox represents $500–700 in cost and $1,000–1,800 in potential revenue. Improper storage destroys inventory value.
Temperature excursions — even brief periods outside the recommended range — can reduce product potency.
Expiration mismanagement is the other major storage-related cost. Practices that order too much or don't rotate stock regularly write off hundreds to thousands of dollars in expired product.
The 24-hour rule: no exceptions
Once any neurotoxin is reconstituted, the clock starts. All six FDA-approved neurotoxins must be used within 24 hours of reconstitution. After that window, unused product must be discarded.
Every reconstituted vial should be labeled with: product name, date and time of reconstitution, expiration (24 hours from reconstitution time), and injector's initials.
Cold chain: receiving and storing shipments
- Inspect on arrival. Check that cold packs are still cold and packaging is intact.
- Refrigerate immediately. For all products except Daxxify, get them into the refrigerator within minutes.
- Verify lot numbers and expiration dates. Log into your inventory system at time of receipt.
- Rotate stock. First-in, first-out (FIFO).
- Separate products. Keep all six products clearly separated in storage.
- Monitor refrigerator temperature. A thermometer inside your storage fridge — checked daily — catches temperature drift.
Room temperature storage: Daxxify and Xeomin
Daxxify
Uses a novel peptide stabilizer (instead of human albumin), which allows unopened vials to be stored at room temperature. After reconstitution, follows the same 24-hour rule.
Xeomin
The "naked" formulation gives it exceptional stability. Unopened vials can be stored at room temperature for up to 36 months — the longest shelf life flexibility of any neurotoxin.
Expiration management best practices
- Set alerts at 90, 60, and 30 days before expiration.
- Review expiring inventory weekly.
- Transfer before it expires. Move slow-moving product to busier locations.
- Order smaller quantities more frequently.
- Track expiration write-offs in dollars. "$1,500 in expired product this quarter" gets attention.
Frequently Asked Questions
How should Botox be stored?
Refrigerate unopened Botox at 2–8°C. Do not freeze. After reconstitution, refrigerate and use within 24 hours.
Does Daxxify need to be refrigerated?
Unopened Daxxify can be stored at room temperature. After reconstitution, use within 24 hours.
Can Xeomin be stored at room temperature?
Yes — unopened Xeomin can be stored at room temperature for up to 36 months.
How long does reconstituted neurotoxin last?
All reconstituted neurotoxins must be used within 24 hours. No exceptions.
What happens if neurotoxin is left out of the refrigerator?
Temperature excursions can reduce potency. When in doubt, discard.
How do you prevent neurotoxin from expiring?
Set expiration alerts at 90, 60, and 30 days. Review weekly. Transfer slow-moving product. Order smaller quantities more frequently.